Acute Toxicity Evaluation of Non-Innocent Oxidovanadium(V) Schiff Base Complex

The vanadium(V) complexes have been investigated as potential anticancer agents which makes it essential to evaluate their toxicity for safe use in the clinic. large-scale synthesis and acute oral mice of oxidovanadium(V) Schiff base catecholate complex, abbreviated [VO(HSHED)dtb] containing a redox-active ligand with tridentate (HSHED = N-(salicylideneaminato)-N’-(2-hydroxyethyl)-1,2-ethylenediamine) dtb 3,5-di-(t-butyl)catechol ligands were carried out. body weight, food consumption, water intake well biomarkers liver kidney compared precursors, sodium orthovanadate, free ligand. 10-fold scale-up complex resulting preparation material improved yield leading 2–3 g (79%) suitable investigating vanadium complex. No evidence was observed animals when acutely exposed single dose 300 mg/kg 14 days. toxicological results obtained biochemical hematological analyses did not show significant changes parameters reference values. low is attributed redox chemistry taking place under biological conditions combined hydrolytic stability These document design that but still are antioxidant agents.